Article

The Tiling Algorithm – A general method for structural characterization of accurate long DNA sequence reads: application to AAV genome sequences

2025-07-31

Abstract excerpt

A deno- a ssociated v irus (AAV), a common vector used in human gene therapy, is challenging for DNA sequencing for several reasons. First, AAV’s replication cycle results in structural rearrangements. Specifically, the inverted terminal repeat (ITR) at each end of the genome as well as the genetic payload can invert independently. Second, the ITR can prime DNA replication of the entire viral genome in the gap f...

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Literature Corpus work: 14cf0334-7202-54c6-8c5d-dab1565300de
DOI: 10.1101/2025.07.25.666743

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