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Native Molecular State of Adeno-Associated Viral Vectors Revealed by Single-Molecule Sequencing

29 Aug 2011

Abstract excerpt

The single-stranded genome of adeno-associated viral (AAV) vectors is one of the key factors leading to slow-rising but long-term transgene expression kinetics. Previous molecular studies have established what is now considered a textbook molecular model of AAV genomes with two copies of inverted tandem repeats at either end. In this study, we profiled hundreds of thousands of individual molecules of AAV vector...

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PMID: 21875357
DOI: 10.1089/hum.2011.160

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