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High-Throughput Sequencing Reveals Principles of Adeno-Associated Virus Serotype 2 Integration

29 May 2013

Abstract excerpt

Viral integrations are important in human biology, yet genome-wide integration profiles have not been determined for many viruses. Adeno-associated virus (AAV) infects most of the human population and is a prevalent gene therapy vector. AAV integrates into the human genome with preference for a single locus, termed AAVS1. However, the genome-wide integration of AAV has not been defined, and the principles...

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PMID: 23720718
DOI: 10.1128/jvi.01135-13

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