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High-fidelity long-read sequencing of an avian herpesvirus reveals extensive intrapopulation diversity in tandem repeat regions.

PLoS pathogens - 1 Aug 2025

Ortigas-Vasquez Alejandro, Bowen Christopher D, Renner Daniel W, Baigent Susan J, Zhang Yaoyao, Yao Yongxiu, Nair Venugopal, Kennedy David A, Szpara Moriah L

Abstract excerpt

Comparative genomic studies of Marek's disease virus (MDV) have suggested that attenuated and virulent strains share >98% sequence identity. However, these estimates fail to account for variation in regions of the MDV genome harboring tandem repeats. To resolve these loci and enable assessments of intrapopulation diversity, we used a PacBio Sequel II platform to sequence MDV strains CVI988/Rispens (attenuated),...

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PMID: 40853964
DOI: 10.1371/journal.ppat.1013435
PMCID: PMC12425393

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