Article

Assessment of genome packaging in AAVs using Orbitrap-based charge detection mass spectrometry

2021-09-02

Abstract excerpt

Adeno-associated viruses (AAV) represent important gene therapy vectors with several approved clinical applications and numerous more in clinical trials. Genome packaging is an essential step in the bioprocessing of AAVs and needs to be tightly monitored to ensure the proper delivery of transgenes and the production of effective drugs. Current methods to monitor genome packaging have limited sensitivity, a high de...

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Literature Corpus work: fd0fe8d0-903a-5377-90dd-3c738fc73877
DOI: 10.1101/2021.09.02.458670

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