Discovery of a new binding site and a possible gain in neomorphic activity in R132H_IDH1.

Abstract excerpt

In the Krebs cycle, isocitrate dehydrogenase 1 (IDH1) catalyses the conversion of isocitrate (ICT) to α-ketoglutarate (α-KG), generating nicotinamide adenine dinucleotide phosphate (NADPH), which helps maintain redox balance, facilitates lipid biosynthesis, and provides protection against oxidative stress. The missense mutation at R132 in IDH1, where an arginine (R) residue is substituted by a histidine (H)...

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