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Article

Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity.

Biochemistry - 4 Feb 2020

Chambers Jennifer M, Miller Wade, Quichocho Giovanni, Upadhye Viraj, Matteo Diego Avellaneda, Bobkov Andrey A, Sohl Christal D, Schiffer Jamie M

Abstract excerpt

Point mutations in human isocitrate dehydrogenase 1 (IDH1) can drive malignancies, including lower-grade gliomas and secondary glioblastomas, chondrosarcomas, and acute myeloid leukemias. These mutations, which usually affect residue R132, ablate the normal activity of catalyzing the NADP+-dependent oxidation of isocitrate to α-ketoglutarate (αKG) while also acquiring a neomorphic activity of reducing αKG to...

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Identifiers

PMID: 31869219
DOI: 10.1021/acs.biochem.9b01023
PMCID: PMC8056971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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