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Article

Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms.

Nature communications - 6 May 2024

Mealka Matthew, Sierra Nicole A, Avellaneda Matteo Diego, Albekioni Elene, Khoury Rachel, Mai Timothy, Conley Brittany M, Coleman Nalani J, Sabo Kaitlyn A, Komives Elizabeth A, Bobkov Andrey A, Cooksy Andrew L, Silletti Steve, Schiffer Jamie M, Huxford Tom, Sohl Christal D

Abstract excerpt

Mutations in human isocitrate dehydrogenase 1 (IDH1) drive tumor formation in a variety of cancers by replacing its conventional activity with a neomorphic activity that generates an oncometabolite. Little is understood of the mechanistic differences among tumor-driving IDH1 mutants. We previously reported that the R132Q mutant unusually preserves conventional activity while catalyzing robust oncometabolite...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 38710674
DOI: 10.1038/s41467-024-48277-2
PMCID: PMC11074275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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