Article

IDH1 and IDH2 mutants identified in cancer lose inhibition by isocitrate because of a change in their binding sites

2018-10-20

Abstract excerpt

IDH1 and IDH2 are human enzymes that convert isocitrate (ICT) into α-ketoglutarate (AKG). However, mutations in positions R132 of IDH1 and R140 and R172 of IDH2 cause these enzymes to convert AKG into 2-hydroxyglutarate (2HG). Concurrently, accumulation of 2HG in the cell is correlated with the development of cancer. This activity change is mainly due to the loss of the competitive inhibition by ICT of these enzym...

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Literature Corpus work: fb388fe2-564e-52b9-8731-d16e8cd69a2a
DOI: 10.1101/425025

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