Article

Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanisms

2024-02-23

Abstract excerpt

<title>Abstract</title> <p>Mutations in human isocitrate dehydrogenase 1 (IDH1) drive tumor formation in a variety of cancers by replacing its conventional activity with a neomorphic activity that generates an oncometabolite. Little is understood of the mechanistic differences among tumor-driving IDH1 mutants. We previously reported that the R132Q mutant uniquely preserves conventional activity while catalyzing r...

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Literature Corpus work: c91a4f88-b724-5d73-8239-e221c28e75a5
DOI: 10.21203/rs.3.rs-3889456/v1

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