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Article

Evaluating Mechanisms of IDH1 Regulation through Site-Specific Acetylation Mimics.

Biomolecules - 16 May 2021

Weeks Joi, Strom Alexandra I, Widjaja Vinnie, Alexander Sati, Pucher Dahra K, Sohl Christal D

Abstract excerpt

Isocitrate dehydrogenase (IDH1) catalyzes the reversible NADP+-dependent oxidation of isocitrate to α-ketoglutarate (αKG). IDH1 mutations, primarily R132H, drive > 80% of low-grade gliomas and secondary glioblastomas and facilitate the NADPH-dependent reduction of αKG to the oncometabolite D-2-hydroxyglutarate (D2HG). While the biochemical features of human WT and mutant IDH1 catalysis have been well-established,...

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Identifiers

PMID: 34065652
DOI: 10.3390/biom11050740
PMCID: PMC8157008

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