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AAV-delivery of diacylglycerol kinase kappa achieves long-term rescue of <i>Fmr1</i> -KO mouse model deficits of fragile X syndrome

2021-04-14

Abstract excerpt

Fragile X syndrome (FXS) is the most frequent form of familial intellectual disability. It results from the lack of the RNA binding protein FMRP and is associated with the overactivation of signaling pathways downstream of mGluRI receptors and upstream of mRNA translation. We previously found that diacylglycerol kinase kappa (DGKk) is a main mRNA target of FMRP in cortical neurons. Here we show that diacylglycerol...

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Literature Corpus work
144e708d-1d4e-57a0-9a3f-e8e03de90a42
DOI
10.1101/2021.04.14.439810
Open publication

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AAV-delivery of diacylglycerol kinase kappa achieves long-term rescue of <i>Fmr1</i> -KO mouse model deficits of fragile X syndromeDOI 10.1101/2021.04.14.439810
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