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Epigenetic regulation of innate immune genes and enhanced interleukin-10 expression underlie chronic subclinical <i>Plasmodium chabaudi</i> infection

2023-02-24

Abstract excerpt

Subclinical (asymptomatic) parasitemia is very common amongst Plasmodium -infected individuals. The immunological mechanisms underlying subclinical parasitemia remain elusive. We investigated the immune regulatory mechanisms behind chronic asymptomatic Plasmodium infection using mice lacking humoral immunity (µMT −/− mice). µMT −/− mice became chronically infected, despite lacking outward signs of disease, and...

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Identifiers and source

Literature Corpus work
e2a16719-6120-59fe-8a26-202b03fe9bab
DOI
10.1101/2023.02.23.529826
Open publication

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Epigenetic regulation of innate immune genes and enhanced interleukin-10 expression underlie chronic subclinical <i>Plasmodium chabaudi</i> infectionDOI 10.1101/2023.02.23.529826
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