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Article

Small heat shock proteins and protein-misfolding diseases.

Current pharmaceutical biotechnology - 1 Feb 2010

Laskowska Ewa, Matuszewska Ewelina, Kuczyńska-Wiśnik Dorota

Abstract excerpt

Small heat shock proteins (sHsps) are molecular chaperones ubiquitously distributed in numerous species, from bacteria to humans. A conserved C-terminal "alpha-crystallin" domain organized in a beta-sheet sandwich and oligomeric structure are common features of sHsps. sHsps protect cells against many kinds of stresses including heat shock, oxidative and osmotic stress. sHsps recognize unfolded proteins, prevent...

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PMID: 20166966
DOI: 10.2174/138920110790909669

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