Article

Sex-biased long non-coding RNAs negatively correlated with sex-opposite protein coding gene co-expression networks in Diversity Outbred mouse liver

2018-02-26

Abstract excerpt

Sex differences in liver gene expression and disease susceptibility are regulated by pituitary growth hormone secretion patterns, which activate sex-dependent liver transcription factors and establish sex-specific chromatin states. Ablation of pituitary hormone by hypophysectomy (hypox) has identified two major classes of liver sex-biased genes, defined by their sex-dependent positive or negative responses to hypo...

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Literature Corpus work: 654ee43d-47f3-58ff-9297-80cea2a8098f
DOI: 10.1101/271668

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