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Article

Plastic and behavioral abnormalities in experimental Huntington's disease: a crucial role for cholinergic interneurons.

Neurobiology of disease - 1 Apr 2006

Picconi Barbara, Passino Enrica, Sgobio Carmelo, Bonsi Paola, Barone Ilaria, Ghiglieri Veronica, Pisani Antonio, Bernardi Giorgio, Ammassari-Teule Martine, Calabresi Paolo

Abstract excerpt

Huntington's disease (HD) is a fatal hereditary neurodegenerative disease causing degeneration of striatal spiny neurons, whereas cholinergic interneurons are spared. This cell-type specific pathology produces an array of abnormalities including involuntary movements, cognitive impairments, and psychiatric disorders. Although the genetic mutation responsible for HD has been identified, little is known about the...

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PMID: 16326108
DOI: 10.1016/j.nbd.2005.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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