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Article

Genetic rescue of CB1 receptors on medium spiny neurons prevents loss of excitatory striatal synapses but not motor impairment in HD mice.

Neurobiology of disease - 1 Nov 2014

Naydenov Alipi V, Sepers Marja D, Swinney Katie, Raymond Lynn A, Palmiter Richard D, Stella Nephi

Abstract excerpt

Huntington's disease (HD) is caused by an expanded polyglutamine repeat in huntingtin protein that disrupts synaptic function in specific neuronal populations and results in characteristic motor, cognitive and affective deficits. Histopathological hallmarks observed in both HD patients and genetic mouse models include the reduced expression of synaptic proteins, reduced medium spiny neuron (MSN) dendritic spine...

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Identifiers

PMID: 25134728
DOI: 10.1016/j.nbd.2014.08.009
PMCID: PMC4180675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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