Article

Digital seed amplification assay for TDP-43 aggregate quantification in CSF

2025-10-15

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> Dementia is commonly caused by underlying pathologies driven by misfolded protein aggregates. Although dementia subtypes have distinct mechanisms, overlapping symptoms make diagnosis without biomarkers difficult. Misdiagnosis has previously hindered drug development by enrolling patients non-specifically in trials. <h4>METHODS</h4> We developed a digital Seed amplificatio...

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Literature Corpus work: 13c3dfd0-fd59-5f0b-9b99-49d8ad19bf9d
DOI: 10.1101/2025.10.14.25338017

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