Article

VPS4 and CHMP7 release centromeres from the nuclear envelope for post-mitotic positioning in daughter nuclei

2026-07-14

Abstract excerpt

Eukaryotic chromosomes occupy ordered configurations within the nucleus, an organization that must be re-established in daughter cells as the nuclear envelope reforms at the end of mitosis. The conserved enzyme VPS4 and ESCRT-III proteins mediate nuclear envelope reformation, yet their role in post-mitotic centromere positioning remains unclear. Here, we develop a chemical genetics approach to analyze the role of...

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Literature Corpus work: 138eb76e-282e-503c-a054-11d8b7fa5dac
DOI: 10.64898/2026.07.13.738224

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