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Article

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2017

Gu Mingyu, LaJoie Dollie, Chen Opal S, von Appen Alexander, Ladinsky Mark S, Redd Michael J, Nikolova Linda, Bjorkman Pamela J, Sundquist Wesley I, Ullman Katharine S, Frost Adam

Abstract excerpt

Endosomal sorting complexes required for transport III (ESCRT-III) proteins have been implicated in sealing the nuclear envelope in mammals, spindle pole body dynamics in fission yeast, and surveillance of defective nuclear pore complexes in budding yeast. Here, we report that Lem2p (LEM2), a member of the LEM (Lap2-Emerin-Man1) family of inner nuclear membrane proteins, and the ESCRT-II/ESCRT-III hybrid protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28242692
DOI: 10.1073/pnas.1613916114
PMCID: PMC5358359

Genes

CHMP7
IST1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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