Article

Novel murine model of human astrovirus infection reveals a cardiovascular tropism

2024-10-03

Abstract excerpt

Astroviruses are a common cause of gastrointestinal disease in humans and have been recognized to cause fatal cases of encephalitis. A major barrier to the study of human-infecting astroviruses is the lack of an in vivo model, as previous attempts failed to identify a suitable host that supports viral replication. We describe a novel murine model of infection using astrovirus VA1/HMO-C (VA1), an astrovirus with h...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 137a0f14-7aea-5ff2-a9da-52a7ad2517fc
DOI: 10.1101/2024.10.03.616429

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel murine model of human astrovirus infection reveals a cardiovascular tropismDOI 10.1101/2024.10.03.616429Read

Astrovirus PathogenesisSemantic proximity Read

Adaptive Immunity Restricts Replication of Novel Murine AstrovirusesSemantic proximity Read

Entry and egress of human astroviruses.Semantic proximity Read

Infection and Propagation of Astrovirus VA1 in Cell CultureSemantic proximity Read

Human influenza A virus causes myocardial and cardiac-specific conduction system infections associated with early inflammation and premature death.Semantic proximity Read

Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscapeSemantic proximity Read

Mouse and human immune responses share neutralization epitopes of HAstV-VA1.Semantic proximity Read

Antigenic determinants of HAstV-VA1 neutralization and their relevance in the human immune responseSemantic proximity Read

Scrutiny of human lung infection by SARS-CoV-2 and associated human immune responses in humanized miceSemantic proximity Read

Beyond the Gastrointestinal Tract: The Emerging and Diverse Tissue Tropisms of Astroviruses.Semantic proximity Read

Type I Interferon Response Limits Astrovirus Replication and Protects against Increased Barrier Permeability In Vitro and In VivoSemantic proximity Read

Isolation of Neutralizing Monoclonal Antibodies to Human Astrovirus and Characterization of Virus Variants That Escape NeutralizationSemantic proximity Read