Article

Scrutiny of human lung infection by SARS-CoV-2 and associated human immune responses in humanized mice

2021-11-05

Abstract excerpt

<h4>ABSTRACT</h4> There is an urgent need for animal models of COVID-19 to study immunopathogenesis and test therapeutic intervenes. In this study we showed that NSG mice engrafted with human lung (HL) tissue (NSG-L mice) could be infected efficiently by SARS-CoV-2, and that live virus capable of infecting Vero cells was found in the HL grafts and multiple organs from infected NSG-L mice. RNA-seq examination iden...

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Literature Corpus work: ab5bef6f-17f9-56d9-9c19-b4c8297c0011
DOI: 10.1101/2021.11.05.466755

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