Human influenza A virus causes myocardial and cardiac-specific conduction system infections associated with early inflammation and premature death.

doi:10.1093/cvr/cvaa117

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Human influenza A virus causes myocardial and cardiac-specific conduction system infections associated with early inflammation and premature death.

Cardiovascular research - 22 Feb 2021

Filgueiras-Rama David, Vasilijevic Jasmina, Jalife Jose, Noujaim Sami F, Alfonso Jose M, Nicolas-Avila Jose A, Gutierrez Celia, Zamarreño Noelia, Hidalgo Andres, Bernabé Alejandro, Cop Christopher Pablo, Ponce-Balbuena Daniela, Guerrero-Serna Guadalupe, Calle Daniel, Desco Manuel, Ruiz-Cabello Jesus, Nieto Amelia, Falcon Ana

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AIMS: Human influenza A virus (hIAV) infection is associated with important cardiovascular complications, although cardiac infection pathophysiology is poorly understood. We aimed to study the ability of hIAV of different pathogenicity to infect the mouse heart, and establish the relationship between the infective capacity and the associated in vivo, cellular and molecular alterations. METHODS AND RESULTS: We...

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Human influenza A virus causes myocardial and cardiac-specific conduction system infections associated with early inflammation and premature death.

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