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Astrovirus replication in human intestinal enteroids reveals multi-cellular tropism and an intricate host innate immune landscape

31 Oct 2019

Abstract excerpt

Human astroviruses (HAstV) are understudied positive-strand RNA viruses that cause gastroenteritis mostly in children and the elderly. Three clades of astroviruses, classic, MLB-type and VA-type have been reported in humans. One limitation towards a better understanding of these viruses has been the lack of a physiologically relevant cell culture model that supports growth of all clades of HAstV. Herein, we...

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PMID: 31671153
DOI: 10.1371/journal.ppat.1008057

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