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Adaptive Immunity Restricts Replication of Novel Murine Astroviruses

6 Sept 2012

Abstract excerpt

The mechanisms of astrovirus pathogenesis are largely unknown, in part due to a lack of a small-animal model of disease. Using shotgun sequencing and a custom analysis pipeline, we identified two novel astroviruses capable of infecting research mice, murine astrovirus (MuAstV) STL1 and STL2. Subsequent analysis revealed the presence of at least two additional viruses (MuAstV STL3 and STL4), suggestive of a...

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PMID: 22951832
DOI: 10.1128/jvi.02018-12

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