Article

Integrated Analysis of Global Regulators and Efflux Genes in MDR Klebsiella pneumoniae:Unlocking Targets for Antimicrobial Reversal

2025-07-22

Abstract excerpt

<title>Abstract</title> Background: Multidrug-resistant Klebsiella pneumoniae poses a growing clinical challenge due to its ability to evade antibiotic treatment, particularly through the overexpression of efflux systems. Among these, the AcrAB-TolC pump is central to resistance against fluoroquinolones. While the global regulator's MarA, SoxS, and Rob are known modulators of efflux in Enterobacteriaceae, thei...

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Literature Corpus work: 134d2a22-75ab-5110-9d4b-40112fec5940
DOI: 10.21203/rs.3.rs-7168743/v1

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