Mutations in the efflux regulator gene oqxR provide a simple genetic switch for antimicrobial resistance in Klebsiella pneumoniae.

Abstract excerpt

Klebsiella pneumoniae is a pathogen of major concern in the global rise of antimicrobial resistance and has been implicated as a reservoir for the transfer of resistance genes between species. The upregulation of efflux pumps is a particularly concerning mechanism of resistance acquisition as, in many instances, a single point mutation can simultaneously provide resistance to a range of antimicrobials and...

Topics

• Anti-Bacterial Agents
• Bacterial Proteins
• Chloramphenicol
• Ciprofloxacin
• Drug Resistance, Bacterial
• Drug Resistance, Multiple, Bacterial
• Gene Expression Regulation, Bacterial
• Klebsiella Infections
• Klebsiella pneumoniae
• Membrane Transport Proteins
• Microbial Sensitivity Tests
• Mutation
• Tetracycline