Article
In vitro selection of ramR and soxR mutants overexpressing efflux systems by fluoroquinolones as well as cefoxitin in Klebsiella pneumoniae.
Antimicrobial agents and chemotherapy - 1 Jun 2011
Bialek-Davenet Suzanne, Marcon Estelle, Leflon-Guibout Véronique, Lavigne Jean-Philippe, Bert Frédéric, Moreau Richard, Nicolas-Chanoine Marie-Hélène
Abstract excerpt
The relationship between efflux system overexpression and cross-resistance to cefoxitin, quinolones, and chloramphenicol has recently been reported in Klebsiella pneumoniae. In 3 previously published clinical isolates and 17 in vitro mutants selected with cefoxitin or fluoroquinolones, mutations in the potential regulator genes of the AcrAB efflux pump (acrR, ramR, ramA, marR, marA, soxR, soxS, and rob) were...
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