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Article

Global regulator SoxR is a negative regulator of efflux pump gene expression and affects antibiotic resistance and fitness in Acinetobacter baumannii.

Medicine - 1 Jun 2017

Li Henan, Wang Qi, Wang Ruobing, Zhang Yawei, Wang Xiaojuan, Wang Hui

Abstract excerpt

SoxR is a global regulator contributing to multidrug resistance in Enterobacteriaceae. However, the contribution of SoxR to antibiotic resistance and fitness in Acinetobacter baumannii has not yet been studied. Comparisons of molecular characteristics were performed between 32 multidrug-resistant A. baumannii isolates and 11 susceptible isolates. A soxR overexpression mutant was constructed, and its resistance...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28614259
DOI: 10.1097/MD.0000000000007188
PMCID: PMC5478344

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