Article

Knocking out CD70 rescues CD70-specific nanoCAR T cells from antigen induced exhaustion

2023-01-22

Abstract excerpt

CD70 is an attractive target for chimeric antigen receptor (CAR) T cell therapy as treatment for both solid and liquid malignancies. However, functionality of CD70-specific CARs is only modest. Here, we optimized a CD70-specific VHH based CAR (nanoCAR). We evaluated the nanoCARs in clinically relevant models in vitro , using co-cultures of CD70-specific nanoCAR T cells with malignant rhabdoid tumor organoids, and...

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Identifiers and source

Literature Corpus work: 13454d3e-7871-5b50-9adc-0799a96f8fa9
DOI: 10.1101/2023.01.22.523482

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