Article

Therapeutically targeting the classical complement pathway with antisense oligonucleotides in Alzheimer’s disease

2024-08-26

Abstract excerpt

The complement classical pathway (CP) is a key mediator of synapse loss and neurodegeneration in mouse models of Alzheimer’s (AD) and other neurodegenerative diseases. We analyzed human brain proteomics and found consistent elevations of all CP proteins, but not other complement pathways, in AD patient brains. We performed human genetics analysis that identified a rare variant in the C1S gene within the Finnish p...

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Literature Corpus work: 130e72ae-6204-513c-891b-c758d4f64f93
DOI: 10.1101/2024.08.23.609240

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