Article
Identification of nonfunctional PABPC1L causing oocyte maturation abnormalities and early embryonic arrest in female primary infertility.
Clinical genetics - 1 Dec 2023
Wang Xiang, Zhou Ruixi, Lu Xiaowei, Dai Siyu, Liu Mohan, Jiang Chuan, Yang Yanting, Shen Ying, Wang Yan, Liu Hanmin
Abstract excerpt
Oocyte maturation arrest, fertilization failure, and early embryonic arrest are important causes of female infertility, whereas the genetic events that contribute to these processes are largely unknown. Loss-of-function of PABPC1L in mice has been suggested to cause female infertility involved in the absence of mature oocytes or embryos in vivo or in vitro. However, the role of PABPC1L in human female...
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