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PATL2 regulates mRNA homeostasis in oocytes by interacting with EIF4E and CPEB1

23 May 2023

Abstract excerpt

The accumulation and storage of maternal mRNA is crucial for oocyte maturation and embryonic development. PATL2 is an oocyte-specific RNA-binding protein, and previous studies have confirmed that PATL2 mutation in humans and knockout mice cause oocyte maturation arrest or embryonic development arrest, respectively. However, the physiological function of PATL2 in the process of oocyte maturation and embryonic...

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PMID: 37218508
DOI: 10.1242/dev.201572

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