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Multi-omics reveals the DR5-FXR-CHPT1 axis governs hepatocyte pyroptosis via glycerophospholipid remodeling after major partial hepatectomy

2026-03-20

Abstract excerpt

<title>Abstract</title> <p>Background & Aims: Acute liver injury following major partial hepatectomy (PHx), manifesting as small-for-size syndrome (SFSS) and post-hepatectomy liver failure (PHLF), carries high mortality. However, the key mechanisms underlying irreversible remnant liver injury and cell death remain poorly understood, particularly regarding the contribution of lipid metabolism. This study investiga...

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Literature Corpus work
72ae33e1-bb2c-5af3-85ac-3d5ec3b08543
DOI
10.21203/rs.3.rs-9039762/v1
Open publication

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Multi-omics reveals the DR5-FXR-CHPT1 axis governs hepatocyte pyroptosis via glycerophospholipid remodeling after major partial hepatectomyDOI 10.21203/rs.3.rs-9039762/v1
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