Article

Identifying and exploiting trait-relevant tissues with multiple functional annotations in genome-wide association studies

2018-01-04

Abstract excerpt

Genome-wide association studies (GWASs) have identified many disease associated loci, the majority of which have unknown biological functions. Understanding the mechanism underlying trait associations requires identifying trait-relevant tissues and investigating associations in a trait-specific fashion. Here, we extend the widely used linear mixed model to incorporate multiple SNP functional annotations from omics...

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Literature Corpus work: 12ab3c20-5d32-5590-9f8b-b73e89e65220
DOI: 10.1101/242990

Open publication

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