Article
A tissue-specific collaborative mixed model for jointly analyzing multiple tissues in transcriptome-wide association studies.
Nucleic acids research - 4 Nov 2020
Shi Xingjie, Chai Xiaoran, Yang Yi, Cheng Qing, Jiao Yuling, Chen Haoyue, Huang Jian, Yang Can, Liu Jin
Abstract excerpt
Transcriptome-wide association studies (TWASs) integrate expression quantitative trait loci (eQTLs) studies with genome-wide association studies (GWASs) to prioritize candidate target genes for complex traits. Several statistical methods have been recently proposed to improve the performance of TWASs in gene prioritization by integrating the expression regulatory information imputed from multiple tissues, and...
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