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Article

Identifying and exploiting trait-relevant tissues with multiple functional annotations in genome-wide association studies.

PLoS genetics - 1 Jan 2018

Hao Xingjie, Zeng Ping, Zhang Shujun, Zhou Xiang

Abstract excerpt

Genome-wide association studies (GWASs) have identified many disease associated loci, the majority of which have unknown biological functions. Understanding the mechanism underlying trait associations requires identifying trait-relevant tissues and investigating associations in a trait-specific fashion. Here, we extend the widely used linear mixed model to incorporate multiple SNP functional annotations from...

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PMID: 29377896
DOI: 10.1371/journal.pgen.1007186
PMCID: PMC5805369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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