Article

Fibroblasts neurotrophin signaling sustains pathological vascular maturation in rheumatoid arthritis

2026-03-15

Abstract excerpt

Treatment failures in rheumatoid arthritis (RA) leads to undesirable morbidity associated with immunosuppression. Recent studies of synovial tissue from refractory RA patients highlight the role of synovial fibroblasts and vascular endothelium in driving treatment failure. Utilizing high-dimensional spatial transcriptomics, we uncovered a crucial role for neurotrophin signaling in driving abnormal vascular maturat...

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Literature Corpus work: 12980c08-c9c4-5e4c-99db-17033cf79bac
DOI: 10.64898/2026.03.12.711120

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