Article
Neuronal sFlt1 and Vegfaa determine venous sprouting and spinal cord vascularization.
Nature communications - 10 Jan 2017
Wild Raphael, Klems Alina, Takamiya Masanari, Hayashi Yuya, Strähle Uwe, Ando Koji, Mochizuki Naoki, van Impel Andreas, Schulte-Merker Stefan, Krueger Janna, Preau Laetitia, le Noble Ferdinand
Abstract excerpt
Formation of organ-specific vasculatures requires cross-talk between developing tissue and specialized endothelial cells. Here we show how developing zebrafish spinal cord neurons coordinate vessel growth through balancing of neuron-derived Vegfaa, with neuronal sFlt1 restricting Vegfaa-Kdrl mediated angiogenesis at the neurovascular interface. Neuron-specific loss of flt1 or increased neuronal vegfaa expression...
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