Article

Modelling leukemia in the mouse : novel strategies in genome engineering

2002-01-01

Abstract excerpt

The work of this thesis presents novel genome engineering strategies for assembling complex targeting vectors for functional studies in the mouse. With the objective of establishing a conditional mouse model of the human acute leukemia associated with the t(4;ll)(q21;q23) translocation, an approach based on the Cre-loxP technology was chosen, and two mouse lines and one ES cell line were engineered starting from B...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 12958454-bb17-52df-ba25-2f2f803b577d
DOI: 10.21954/ou.ro.0000fd34

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Modelling leukemia in the mouse : novel strategies in genome engineeringDOI 10.21954/ou.ro.0000fd34Read

Dissecting the early steps of MLL induced leukaemogenic transformation using a new mouse model of AMLSemantic proximity Read

Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles.Semantic proximity Read

Evaluation of current mouse in vivo models and advanced in vitro models for leukaemia researchSemantic proximity Read

Genome engineering via homologous recombination in mouse embryonic stem (ES) cells: an amazingly versatile tool for the study of mammalian biology.Semantic proximity Read

Murine Models of Acute Myeloid LeukaemiaSemantic proximity Read

Modeling chromosomal translocations using conditional alleles to recapitulate initiating events in human leukemias.Semantic proximity Read

Advances in the development of animal models of myeloid leukemias.Semantic proximity Read

Mouse models of MLL leukemia: recapitulating the human diseaseSemantic proximity Read

A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology.Semantic proximity Read

Constitutive Kit activity triggers B-cell acute lymphoblastic leukemia-like disease in mice.Semantic proximity Read

Sequential gene targeting to make chimeric tumor models with de novo chromosomal abnormalities.Semantic proximity Read

Knock-in approaches.Semantic proximity Read