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Emerging Role of Genetic Alterations Affecting Exosome Biology in Neurodegenerative Diseases

23 Aug 2019

Abstract excerpt

The abnormal deposition of proteins in brain tissue is a common feature of neurodegenerative diseases (NDs) often accompanied by the spread of mutated proteins, causing neuronal toxicity. Exosomes play a fundamental role on their releasing in extracellular space after endosomal pathway activation, allowing to remove protein aggregates by lysosomal degradation or their inclusion into multivesicular bodies (MVBs),...

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PMID: 31450727
DOI: 10.3390/ijms20174113

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