Article

KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication

2018-10-12

Abstract excerpt

Herpesviruses usurp host cell protein synthesis machinery to convert viral mRNAs into proteins, and the endoplasmic reticulum (ER) to ensure proper folding, post-translational modification and trafficking of secreted viral proteins. Overloading ER folding capacity activates the unfolded protein response (UPR), whereby displacement of the ER chaperone BiP activates UPR sensor proteins ATF6, PERK and IRE1 to initiat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 128467c7-3230-5756-9ce5-f8e20a2cd0ee
DOI: 10.1101/442079

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replicationDOI 10.1101/442079Read

KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replicationSemantic proximity Read

Herpes simplex virus-1 disarms the unfolded protein response in the early stages of infectionSemantic proximity Read

BiP/GRP78 is a pro-viral factor for diverse dsDNA viruses that promotes the survival and proliferation of cells upon KSHV infectionSemantic proximity Read

A Viral-Encoded Homologue of IPS-1 Modulates Innate Immune Signaling During KSHV Lytic ReplicationSemantic proximity Read

Analysis of the ubiquitin-modified proteome identifies novel host factors in Kaposi’s sarcoma herpesvirus lytic reactivationSemantic proximity Read

Repression of viral gene expression and replication by the unfolded protein response effector XBP1uSemantic proximity Read

Induction of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Thymidine Kinase (ORF21) by X-Box Binding Protein 1.Semantic proximity Read

Screening of the Human Kinome Identifies MSK1/2-CREB1 as an Essential Pathway Mediating Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication during Primary InfectionSemantic proximity Read

Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virusSemantic proximity Read

Archaic translation initiation factor eIF5B supports KSHV late lytic replication and viral oncogenesis by mimicking a hypoxic cellular landscapeSemantic proximity Read

Oncogenic Herpesvirus Utilizes Stress-Induced Cell Cycle Checkpoints for Efficient Lytic ReplicationSemantic proximity Read

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cellsSemantic proximity Read