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Article

KSHV activates unfolded protein response sensors but suppresses downstream transcriptional responses to support lytic replication

2 Dec 2019

Abstract excerpt

Herpesviruses usurp host cell protein synthesis machinery to convert viral mRNAs into proteins, and the endoplasmic reticulum (ER) to ensure proper folding, post-translational modification and trafficking of secreted and transmembrane viral proteins. Overloading ER folding capacity activates the unfolded protein response (UPR), whereby sensor proteins ATF6, PERK and IRE1 initiate a stress-mitigating transcription...

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Share to Cytomegalovirus and herpesvirus research
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PMID: 31790507
DOI: 10.1371/journal.ppat.1008185

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