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KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation

18 Jan 2011

Abstract excerpt

Kaposi sarcoma-associated herpesvirus (KSHV; also known as HHV8) is the causative agent of two B cell tumors, multicentric Castleman disease (MCD) and primary effusion lymphoma (PEL). However, little is known about the nature of the specific B cell subtype(s) most susceptible to infection. Identifying these cells would provide direct insight into KSHV transmission and virus-induced transformation. To identify...

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PMID: 21245574
DOI: 10.1172/jci44185

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