Article

Single Cell Expression Analysis of Ductal Carcinoma in Situ Identifies Complex Genotypic-Phenotypic Relationships Altering Epithelial Composition

2023-10-12

Abstract excerpt

<h4>ABSTRACT</h4> To identify mechanisms underlying the growth of ductal carcinoma in situ (DCIS) and properties that lead to progression to invasive cancer, we performed single-cell RNA-sequencing (scRNA-seq) on DCIS lesions and matched synchronous normal breast tissue. Using inferred copy number variations (CNV), we identified neoplastic epithelial cells from the clinical specimens which contained a mixture of...

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Literature Corpus work: 125a302f-894b-5461-94c8-bebecbc572e6
DOI: 10.1101/2023.10.10.561724

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