Article
Single-Cell Expression Analysis of Ductal Carcinoma In Situ Identifies Complex Genotypic-Phenotypic Relationships Altering Epithelial Composition.
Cancer research - 16 Jun 2025
Qin Xiaodi, Strand Siri H, Lee Marissa R, Saraswathibhatla Aashrith, van IJzendoorn David G P, Zhu ChunFang, Vennam Sujay, Varma Sushama, Hall Allison, Factor Rachel E, King Lorraine, Simpson Lunden, Luo Xiaoke, Colditz Graham A, Jiang Shu, Chaudhuri Ovijit, Hwang E Shelley, Marks Jeffrey R, Owzar Kouros, West Robert B
Abstract excerpt
Ductal carcinoma in situ (DCIS) is a risk factor for subsequent invasive breast cancer (IBC). To identify events in DCIS that lead to invasive cancer, we performed single-cell RNA sequencing on DCIS lesions and matched normal breast tissue. Inferred copy-number variation was used to identify neoplastic epithelial cells from clinical specimens, which contained a mixture of DCIS and normal ducts. Phylogenetic...
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