Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sumoylation and the function of CCAAT enhancer binding protein alpha (C/EBP alpha).

Blood cells, molecules & diseases - 1 Jan 2000

Khanna-Gupta Arati

Abstract excerpt

CCAAT enhancer binding protein alpha (C/EBP alpha) is the founding member of a family of basic region/leucine zipper (bZIP) transcription factors and is a master regulator of granulopoiesis. It is expressed at high levels throughout myeloid differentiation and binds to the promoters of multiple myeloid-specific genes at different stages of myeloid maturation. Profound hematopoietic abnormalities occur in mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCAAT-Enhancer-Binding Protein-alpha
Share to Leukemia, Myeloid, Acute
Share to Myelopoiesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphorylation

Share to Protein Processing, Post-Translational

Share to Signal Transduction

Share to Small Ubiquitin-Related Modifier Proteins

Share to Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 18406180
DOI: 10.1016/j.bcmd.2008.02.011
PMCID: PMC2505045

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sumoylation and the function of CCAAT enhancer binding protein alpha (C/EBP alpha).PMID 18406180Read ↗

C/EBPα in normal and malignant myelopoiesis.Semantic proximity Read ↗

Expression and regulation of C/EBPα in normal myelopoiesis and in malignant transformation.Semantic proximity Read ↗

Regulation of the C/EBPα signaling pathway in acute myeloid leukemia (Review)Semantic proximity Read ↗

The amino terminal and E2F interaction domains are critical for C/EBP alpha-mediated induction of granulopoietic development of hematopoietic cells.Semantic proximity Read ↗

Arginine methylation of the p30 C/EBPα oncoprotein regulates progenitor proliferation and myeloid differentiationSemantic proximity Read ↗

C/EBPα dysregulation in AML and ALL.Semantic proximity Read ↗

Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3.Semantic proximity Read ↗

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia.Semantic proximity Read ↗

C/EBPα deregulation as a paradigm for leukemogenesis.Semantic proximity Read ↗

SUMO modification of Stra13 is required for repression of cyclin D1 expression and cellular growth arrest.Semantic proximity Read ↗

Transcription factor C/EBPα-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemiaSemantic proximity Read ↗

A dominant-negative mutant of C/EBPalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.