Exploring Hepatocellular Carcinoma Etiology through Multi-omics Bioinformatics

Abstract excerpt

<title>Abstract</title> <p>Background Hepatocellular carcinoma (HCC) ranks as the sixth most common cancer globally, with increasing mortality and persistent therapeutic challenges. Emerging evidence suggests that the immune microenvironment, metabolic reprogramming, and gut microbiota dysbiosis play critical roles in HCC pathogenesis, though their causal effects are unclear. This study used Mendelian randomizat...

Topics

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• Carcinoma, Hepatocellular
• Case-Control Studies
• Causality
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Liver Neoplasms
• Mendelian Randomization Analysis
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

12287957-a010-5d5e-91c3-6055ca1c834c

DOI

10.21203/rs.3.rs-6188338/v1