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Article

Multi-omics SMR and experimental supportive analyses decipher causal drivers hepatocellular carcinoma.

BMC cancer - 16 Feb 2026

Yang Zhiya, Li Tingyang, Shen Jiayun, Huang Yao, Lei Chao, Yu Jiarui, Ma Zhaochen, Zhang Ming, Li Ying

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) is a highly prevalent and fatal digestive system malignancy, challenging to treat due to its latent onset and non-specific symptoms in advanced stages. Somatic mutations play a crucial role in hepatocarcinogenesis, with nearly half of HCC patients carrying oncogenic driver mutations such as TP53, CTNNB1, or TERT. In parallel, germline susceptibility variants identified...

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Topics

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Share to Carcinoma, Hepatocellular
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Liver Neoplasms

Share to Multiomics

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 41699549
DOI: 10.1186/s12885-026-15667-2
PMCID: PMC13101365

Genes

ST6GAL1
JUND
LY9
TERT
CD4
CTNNB1
LGALS1
MBOAT7
PNPLA3
PSMB1
SHMT1
TM6SF2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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