Causal Links Between Circulating Immune Traits and Hepatocellular Carcinoma: A Bi- Directional Mendelian Randomization Study

Abstract excerpt

<h4>Background: </h4> The intricate relationship between the immune system and hepatocellular carcinoma (HCC) profoundly shapes its occurrence, progress, treatment, and ultimate prognosis. While observational studies have uncovered robust correlations between circulating immune traits and HCC, the genetic basis underlying these immune traits and their potential causal connections to HCC remain unclear. Methods In...

Topics

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• Carcinoma, Hepatocellular
• Case-Control Studies
• Causality
• Genetic Predisposition to Disease
• Genome-Wide Association Study
• Liver Neoplasms
• Mendelian Randomization Analysis
• Polymorphism, Single Nucleotide

Identifiers and source

Literature Corpus work

bb1866d6-9801-50bc-8e32-12f1cec0207f

DOI

10.21203/rs.3.rs-4195828/v1